2025 Anime Rankings | Top 20 Best Character Duos Voted by Spacomic

In anime works, besides the captivating plots, the deep bonds between characters are often the highlight that fans love to talk about most. Whether they are comrades fighting together, childhood friends who grew up together, or sworn enemies who love and hate each other, these character pairs with the best relationships always spark countless discussions.

In December 2025, the well-known Japanese anime voting site Spacomic (スパコミック) announced the latest reader poll results: "The Character Pairs with the Best Relationship (仲がいいキャラペア)". This list covers classic long-running masterpieces like ONE PIECE and Hunter x Hunter, and also reflects the astonishing popularity of emerging works like Hundred Note.

Below is a complete analysis of this TOP 20 ranking—check quickly to see if your favorite CP made the list!

20th to 11th Place: A Brilliant Clash of Classic Anime and Emerging Works

This part of the ranking shows the stable popularity of classic works and the rise of characters from recent popular mobile games.

• 20th: Maehara Hiroto & Isogai Yuma (Maehara Hiroto & Isogai Yuma)

  • From: Assassination Classroom
  • The "Handsome Duo" of Class 3-E, they have perfect synergy and complement each other excellently in leadership and action.

• 19th: Sakuma Ritsu & Isara Mao (Sakuma Ritsu & Isara Mao)

  • From: Ensemble Stars!!
  • A famous childhood friend duo; their wordless familiarity always warms fans' hearts.

• 18th: Luffy & Zoro (Luffy & Zoro)

  • Source: "ONE PIECE" (ONE PIECE)
  • The captain and his first crewmate. Zoro's unconditional trust in Luffy and Luffy's reliance on Zoro are the cornerstone of the Straw Hat Pirates.

• 17th Place: Jade & Floyd (Leech Brothers) (Jade & Floyd)

  • Source: "Disney Twisted-Wonderland" (Disney Twisted-Wonderland)
  • The Leech twin brothers have contrasting personalities, but their unique brotherly connection and默契 (默契) is unmatched.

• 16th Place: Naruto & Sasuke (Naruto & Sasuke)

  • Source: "NARUTO" (NARUTO)
  • The bond from rivals to best friends runs through the entire work, making them one of the most classic "love-hate relationship" representatives in anime history.

• 15th Place: Tenmei Daichi & Kiri Tatehito (Tenmei Daichi & Kiri Tatehito)

  • From: Hundred Note (ハンドレッドノート)
  • Kodansha's new-generation detective project shines on this list, with their interactions full of the fun sparks of a new-gen detective duo.

• 14th Place: Yozakura Shion & Yozakura Kengo (Yozakura Shion & Yozakura Kengo)

  • Source: "Mission: Yozakura Family" (Mission: Yozakura Family)
  • The Yozakura family's sibling duo is usually noisy and quarrelsome, but the familial love they show in critical moments is touching.

• 13th Place: Traveler & Paimon (Traveler & Paimon)

  • Source: "Genshin Impact" (Genshin Impact)
  • The best guide and emergency food in Teyvat, this pair of adventure partners are inseparable.

• 12th Place: Nagi Seishiro & Mikage Reo (Nagi Seishiro & Mikage Reo)

  • Source: "Blue Lock" (BLUE LOCK)
  • From discovering their talents to parting ways and reconnecting, the evolution of their relationship is one of the most dramatic highlights in "Blue Lock".

• 11th Place: Trailblazer & Dan Heng (Trailblazer & Dan Heng)

  • From: "Honkai: Star Rail" (Honkai: Star Rail)
  • Reliable companions of the Express Crew. The calm Dan Heng and the Trailblazer who often acts out of line create an interesting chemical reaction.

10th to 4th Place: The Extremely Popular Golden Duos

Entering the top ten, the competition becomes even fiercer, gathering the soul duos from various popular works.

• 10th: Hinata Shoyo & Kageyama Tobio (Hinata Shoyo & Kageyama Tobio)